Parts of the body are often embedded in the structure of compound words, such asheartbreakandbrainchild. We explored the relationships between the semantics of compounds and their constituent body parts, asking whether these relationships are largely arbitrary or instead reflect deeper metaphorical mappings shared across languages and cultures. In three studies, we found that U.S. English speakers associated the English translation equivalents of Chinese compounds with their constituent body parts at rates well above chance, even for compounds with highly abstract meanings (...) and even when accounting for the semantic relatedness of the compounds and body parts. English speakers in India and Chinese speakers in Hong Kong showed similar intuitions about these associations. Our results suggest that the structure of compound words can provide insight into cross‐culturally shared ways of connecting meaning to the body. (shrink)

We argue that for theorists with a post-institutional conception of property, e.g., Rawlsians, there is no principled reason to limit the domain of distributive justice to tax and transfer-both tax policy and the rules of the private law are constructed in service to distributive aims. Such theorists cannot maintain a commitment to a normative conception of private law independent of their overarching distributive principles. In contrast, theorists with a pre-institutional conception of property can derive the private law from sectors of (...) morality independent of distributive justice. Nevertheless, we argue, this does not entail that the private law, for pre-institutional theorists, must be sanitized of equity-oriented values. Non-libertarian pre-institutional theorists holding principled commitments to equity-oriented values are free to invoke either tax and transfer or the rules of the private law to attain them. Footnotesa We are grateful to John G. Bennett, Harry Dolan, Edward McCaffery, and Ellen Frankel Paul for written comments on a previous draft and to Eric Mack, Fred Miller, Jeffrey Paul, A. John Simmons, and the other contributors to this volume for valuable discussions. (shrink)

We thank Leo Lam and Taylor Nichols for their response1 to our paper ‘COVID-19 vaccine boosters for young adults: a risk–benefit assessment and ethical analysis of mandate policies at universities’.2 In our paper, we demonstrate that the risk–benefit calculus to mandate boosters for young adults aged 18–29 is a net risk intervention. The authors assert that we have made three inappropriate comparisons of benefits versus risks of the mRNA vaccine booster dose in this age group. We provide our response to (...) each below. We erred on the side of overestimating benefits of the booster dose against severe COVID-19 in this age group and still found net harms to outweigh net benefits. The conclusion of our paper holds, and university booster mandates for young people were—and remain—unethical. For the first comparison, we weighed predicted hospitalisations prevented by one booster dose of BNT162b2 with vaccine-associated SAEs from the manufacturer’s randomised trial (3/5055).3 We found that the rate of expected SAEs would outweigh the benefits of the booster against hospitalisation by at least 18-fold. Lam and Nichols suggest that this was an inappropriate comparison, as not all SAEs result in hospitalisation. However, the definition of SAE as used in the trial included death, hospitalisation, disability, permanent damage, life-threatening event or condition, which required medical or surgical intervention to prevent a serious outcome.4 While all comparisons include some degree of incommensurability, comparing these SAEs with hospitalisations prevented by the booster is more reasonable than Lam and Nichols’ suggestion of comparing SAEs to infections prevented. The COVID-19 infection hospitalisation risk in this age group was <0.5% (or <1/200)5 even prior to widespread immunity, thus comparing SAEs to infection risk is entirely inappropriate. Furthermore, a booster dose will only offer transient (if any) protection against infection6 and cumulative infection rates …. (shrink)

Observers inspected normal, high quality color displays of everyday visual scenes while their eye movements were recorded. A large display change occurred each time an eye blink occurred. Display changes could either involve "Central Interest" or "Marginal Interest" locations, as determined from descriptions obtained from independent judges in a prior pilot experiment. Visual salience, as determined by luminance, color, and position of the Central and Marginal interest changes were equalized. -/- The results obtained were very similar to those obtained in (...) prior experiments showing failure to detect changes occurring simultaneously with saccades, flicker, or “mudsplashes” in the visual scene: Many changes were very hard to detect, and Marginal Interest changes were harder to detect than Central Interest changes. -/- Analysis of eye movements showed, as expected, that the probability of detecting a change depended on the eye’s distance from the change location. However a surprising finding was that both for Central and Marginal Interest changes, evenwhen observers were directly fixating the change locations (within 1 degree),more than 40% of the time they still failed to see the changes. It seems that looking at something does not guarantee you “ see” it. (shrink)

Although informed consent is important in clinical research, questions persist regarding when it is necessary, what it requires, and how it should be obtained. The standard view in research ethics is that the function of informed consent is to respect individual autonomy. However, consent processes are multidimensional and serve other ethical functions as well. These functions deserve particular attention when barriers to consent exist. We argue that consent serves seven ethically important and conceptually distinct functions. The first four functions pertain (...) principally to individual participants: (1) providing transparency; (2) allowing control and authorization; (3) promoting concordance with participants' values; and (4) protecting and promoting welfare interests. Three other functions are systemic or policy focused: (5) promoting trust; (6) satisfying regulatory requirements; and (7) promoting integrity in research. Reframing consent around these functions can guide approaches to consent that are context sensitive and that maximize achievable goals. (shrink)

Pragmatic clinical trials offer important benefits, such as generating evidence that is suited to inform real-world health care decisions and increasing research efficiency. However, PCTs also present ethical challenges. One such challenge involves the management of information that emerges in a PCT that is unrelated to the primary research question, yet may have implications for the individual patients, clinicians, or health care systems from whom or within which research data were collected. We term these findings as?pragmatic clinical trial collateral findings,? (...) or?PCT-CFs?. In this article, we explore the ethical considerations associated with the identification, assessment, and management of PCT-CFs, and how these considerations may vary based upon the attributes of a specific PCT. Our purpose is to map the terrain of PCT-CFs to serve as a foundation for future scholarship as well as policy-making and to facilitate careful deliberation about actual cases as they occur in practice. (shrink)

BackgroundClinical ethics consultations can be complex interventions, involving multiple methods, stakeholders, and competing ethical values. Despite longstanding calls for rigorous evaluation in the field, progress has been limited. The Medical Research Council proposed guidelines for evaluating the effectiveness of complex interventions. The evaluation of CEC may benefit from application of the MRC framework to advance the transparency and methodological rigor of this field. A first step is to understand the outcomes measured in evaluations of CEC in healthcare settings. ObjectiveThe primary (...) objective of this review was to identify and map the outcomes reported in primary studies of CEC. The secondary objective was to provide a comprehensive overview of CEC structures, processes, and roles to enhance understanding and to inform standardization.MethodsWe searched electronic databases to identify primary studies of CEC involving patients, substitute decision-makers and/or family members, clinicians, healthcare staff and leaders. Outcomes were mapped across five conceptual domains as identified a priori based on our clinical ethics experience and preliminary literature searches and revised based on our emerging interpretation of the data. These domains included personal factors, process factors, clinical factors, quality, and resource factors. ResultsForty-eight studies were included in the review. Studies were highly heterogeneous and varied considerably regarding format and process of ethical intervention, credentials of interventionist, population of study, outcomes reported, and measures employed. In addition, few studies used validated measurement tools. The top three outcome domains that studies reported on were quality, process factors, and clinical factors. The majority of studies examined multiple outcome domains. All five outcome domains were multidimensional and included a variety of subthemes.ConclusionsThis scoping review represents the initial phase of mapping the outcomes reported in primary studies of CEC and identifying gaps in the evidence. The confirmed lack of standardization represents a hindrance to the provision of high quality intervention and CEC scientific progress. Insights gained can inform the development of a core outcome set to standardize outcome measures in CEC evaluation research and enable scientifically rigorous efficacy trials of CEC. (shrink)

According to H.L.A. Hart's analysis, to utter an internal legal statement is partly to express an acceptance of a set of norms. This article attempts to defend Hart's conception of internal legal discourse by responding to the following three lines of criticism that can be found in Joseph Raz's writings: (i) that Hart's analysis fails to account for what Raz calls ‘detached legal statements’; (ii) that Hart's deployment of the notion of acceptance in his analysis vitiates his legal positivist project (...) because such acceptance necessarily amounts to moral endorsement; and (iii) that Hart is wrong to assume that normative practices, including discursive legal practices, can be characterized satisfactorily by deploying only descriptive statements. I argue that Hart's theory, or at least a theory along the lines that Hart developed, has sufficient resources to handle satisfactorily these criticisms. His world is a noonday world in which sharply outlined figures, most of them more than a little singular, act in describable ways against perceptible backgrounds. Clifford Geertz, speaking of Sir Edward Evan Evans-Pritchard. (shrink)

It has been asserted that preaching in the first half of the twenty-first century is in crisis by the authors of Engaging Preaching. This crisis has arisen, so say the authors, due in part to those who have been entrusted to preach the ‘oracles of God’ (1 Peter 4:11), having failed to faithfully proclaim the Word of the Lord. No longer do the words of ‘Thus saith the Lord’, regularly fill the halls of the sanctuary. Instead of a sure word (...) from the Bible, those in attendance are just as likely to give tips on self-fulfillment or achieving one’s dreams. By this practice, it seems there are a significant number of pulpit practitioners who neither trust in the authority or the sufficiency of the Word of God. The situation seems bleak, but there is a remedy to be applied to this situation. Carl F. H. Henry has left us a wealth of theological writings that speak to this very problem. This paper will argue as Henry has masterfully argued for the authority of Scripture, the preacher finds a sure footing for a pulpit practice that displays the authority and the sufficiency of the Bible. It will be argued that expositional preaching is the most natural response to a robust view of the authority and sufficiency of the Word of God. (shrink)

In his recent The Parmenidean Ascent, Michael Della Rocca develops a regress-theoretic case, reminiscent of F.H. Bradley’s famous argument in Appearance and Reality, against the intelligibility of relations and in favor of a monistic conception of reality. I argue that Della Rocca illicitly supposes that “internal” relations – in one sense of that word – lead to a “chain” regress, a regress of relations relating relations and relata. In contrast, I contend that if “internal” or grounded relations lead to a (...) regress at all, it is a kind of “fission” regress within the relata themselves, and that a chain regress for relations only arises, if at all, for so-called “external” relations, relations not grounded in their relata. In this way, I contend that Della Rocca pursues a regress for so-called “internal” or grounded relations that only arises, if at all, for so-called “external” relations, relations not grounded in their relata. I compare Della Rocca’s case against relations with Bradley’s reasoning in Appearance and Reality, and suggest in this context that Bradley may, perhaps, have the upper hand. (shrink)

This paper criticises Kevin Toh’s expressivist reconstruction of H. L. A. Hart’s semantics of legal statements on the grounds that two implications of Toh’s reading are arguably too disruptive to Hart’s theory of law. The first of these implications is that legal statements are rendered indistinguishable from statements of value. The second is that the concept of a rule of recognition is rendered dispensable. I argue for the unacceptability of these consequences from a Hartian standpoint in the first two (...) sections of this paper. The last two sections present an alternative view of Hart’s semantics of legal statements, according to which legal normativity is explained in terms of conformity to patterns of validity that by themselves neither provide objective reasons for action nor entail subjective acceptance of such reasons. (shrink)

In his recent _The Parmenidean Ascent_, Michael Della Rocca develops a regress-theoretic case, reminiscent of F. H. Bradley’s famous argument in _Appearance and Reality_, against the intelligibility of relations and in favor of a monistic conception of reality. I argue that Della Rocca illicitly supposes that “internal” relations — in one sense of that word — lead to a “chain” regress, a regress of relations relating relations and relata. In contrast, I contend that if “internal” or grounded relations lead to (...) a regress at all, it is a kind of “fission” regress within the relata themselves, and that a chain regress for relations only arises, if at all, for so-called “external” relations, relations not grounded in their relata. In this way, I contend that Della Rocca pursues a regress for so-called “internal” or grounded relations that only arise, if at all, for so-called “external” relations, relations not grounded in their relata. I compare Della Rocca’s case against relations with Bradley’s reasoning in _Appearance and Reality_ and suggest in this context that Bradley may, perhaps, have the upper hand. (shrink)

Exceptionally Common Courage provides an extended, close reading of Fear and Trembling, Kierkegaard's well-known, pseudonymous book about Abraham's sacrifice of Isaac. It then fits this (in)famous work into the broader and puzzling corpus that includes both other pseudonymous works and signed discourses by this same mercurial author. Though not the first to tackle Kierkegaard from the direction of either a single work or the whole authorship, this two-in-one book relates whole and part to whole and part in a way that (...) reads like a genuine musical counterpoint. The scholarly debates inevitably generated by any treatment of Fear and Trembling are here addressed in ways that arise from a detailed interpretation of the text itself without letting secondary material interrupt the primary train of thought. Along the way, Kierkegaard's ideas are brought into conversation with a much broader than usual cannon of interlocutors, including such figures as Elizabeth Stuart Phelps and James Baldwin, R.H. Tawney and Wendell Berry. And by the end, the complex movement of the entire authorship becomes audible above the various isolated and doctrinaire notes typically highlighted in comparable studies. The recurring melody is about existential courage, about the risk of emotionally investing in earthly goods against the ambiguous inevitability of their loss. Woven throughout Kierkegaard's so-called esthetic and religious writings, this common task of facing threats to the integral meaning of human experience stands out in arresting color. As the chapters unfold, this understanding of faith as a form of courage provides not just direction, but a topographical score for what is originally a highly indirect and elusive textual arrangement. (shrink)

Early Analytic Philosophy: An Inclusive Reader With Commentary contains the most important readings in the development of the analytic tradition in philosophy. Featuring primary source material accompanied by introductions and commentaries, it brings together work by thinkers at the origins of the tradition. Beginning in the 1890s with F.H. Bradley and ending in the 1950s with W.V.O Quine, each chapter includes readings from a particular thinker or movement. Background information and further reading recommendations appear alongside discussion of the main ideas (...) in the readings. Covering well-known figures such as Bertrand Russell, Ludwig Wittgenstein and G.E. Moore, this reader also highlights the central role of neglected figures, such as E.E. Constance Jones and her logical writings, and L. Susan Stebbing's work on analysis and scientific discourse. (shrink)

Edmund D. Pellegrino has played a central role in shaping the fields of bioethics and the philosophy of medicine. His writings encompass original explorations of the healing relationship, the need to place humanism in the medical curriculum, the nature of the patient’s good, and the importance of a virtue-based normative ethics for health care. In this anthology, H. Tristram Engelhardt, Jr., and Fabrice Jotterand have created a rich presentation of Pellegrino’s thought and its development. Pellegrino’s work has been dedicated to (...) showing that bioethics must be understood in the context of medical humanities, and that medical humanities, in turn, must be understood in the context of the philosophy of medicine. Arguing that bioethics should not be restricted to topics such as abortion, third-party-assisted reproduction, physician-assisted suicide, or cloning, Pellegrino has instead stressed that such issues are shaped by foundational views regarding the nature of the physician-patient relationship and the goals of medicine, which are the proper focus of the philosophy of medicine. This volume includes a preface by Dr. Pellegrino and a comprehensive Introduction by the editors. Of interest to medical ethicists as well as students, scholars, and physicians, _The Philosophy of Medicine Reborn_ offers fascinating insights into the emergence of a field and the work of one of its pioneers. “After a long period of dormancy, philosophy of medicine has blossomed with new life. The single most important physician-philosopher in that rebirth has been Edmund Pellegrino. His contributions to virtue theory, the concept of beneficence, the dispute over the internal and external sources of a morality for medicine, and the role of the Hippocratic tradition are all critical. The essays collected in this volume have changed the history of the philosophy of medicine. He shows that philosophy of medicine can be done with both passion and compassion.” —_Robert M. Veatch, Kennedy Institute of Ethics, Georgetown University_ “Edmund Pellegrino's words have helped medical students, faculty, scholars and patients address the challenges they encounter in medicine and medical practice. His personal support has also been critical for many of us in developing programs in medical ethics and philosophy of medicine in our universities. Dr. Pellegrino combines the wisdom of a great physician with those of a great philosopher to produce a body of writing that will continue to inspire us all. This volume contains some of his best and most influential work.” —_Loretta Kopelman, The Brody School of Medicine, East Carolina University_ _ _ “Edmund Pellegrino has been a leading light in the philosophy of medicine for a generation. He was instrumental in the birth of bioethics, founded one of the leading journals, and provided able leadership in organizing early activities of the profession. He has served as department chairman, dean, and university president. Most recently, he chairs the President’s Council on Bioethics. In all this, first and foremost, he has been a physician. Those who are ill and suffering make a claim upon him. To respond to this claim, Pellegrino creatively brings together the worlds of science and of the humanities. For him, that is what medicine is about, making it the most scientific of the humanities and the most humane of the sciences. Fortunately for us, Pellegrino brings these worlds together in thought, as well as in practice. In this selection from his writings, Engelhardt and Jotterand have captured the heart of Pellegrino’s project, both in depth and breadth, so we can also hear that claim of the ill and so we can see what worlds must come together if we are to respond in the appropriate way.” —_George Khushf, University of South Carolina_ “Pellegrino’s work is both a treasure and important for understanding bioethics. His work in philosophy of medicine addresses the crucial questions that are so important to understanding the practice of medicine and the ethics of health care.” —_Kevin Wildes, President, Loyola University_ _ _. (shrink)

A long history of research has revealed many neurophysiological changes and concomitant behavioral impacts of sleep deprivation, sleep restriction, and circadian rhythms. Little research, however, has been conducted in the area of computational cognitive modeling to understand the information processing mechanisms through which neurobehavioral factors operate to produce degradations in human performance. Our approach to understanding this relationship is to link predictions of overall cognitive functioning, or alertness, from existing biomathematical models to information processing parameters in a cognitive architecture, leveraging (...) the strengths from each to develop a more comprehensive explanation. The integration of these methodologies is used to account for changes in human performance on a sustained attention task across 88 h of total sleep deprivation. The integrated model captures changes due to time awake and circadian rhythms, and it also provides an account for underlying changes in the cognitive processes that give rise to those effects. The results show the potential for developing mechanistic accounts of how fatigue impacts cognition, and they illustrate the increased explanatory power that is possible by combining theoretical insights from multiple methodologies. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Ethical Theory and Responsibility Ethics: A Metaethical Study of Niebuhr and Levinas by Kevin JungMichael SohnEthical Theory and Responsibility Ethics: A Metaethical Study of Niebuhr and Levinas KEVIN JUNG Frankfurt am Main: Peter Lang, 2011. 237 pp. $69.95In Ethical Theory and Responsibility Ethics, Kevin Jung presents a historical and constructive analysis of two of the most prominent defenders of responsibility ethics: H. Richard Niebuhr and (...) Emmanuel Levinas. The Niebuhr and Levinas specialist will find detailed, historical discussions and clear, rigorous analyses of these thinkers’ philosophical and theological thought. But where Jung’s project really makes a distinct contribution to the field of ethics—and where his work may be of interest to the nonspecialist—is when he brings their insights and oversights into critical conversation with analytic philosophy. Rendering a mutually productive dialogue, he persuasively argues that categories within analytic philosophy cohere with and clarify their respective positions; conversely, their concrete responsibility ethics may contribute to analytic philosophy. [End Page 223]Chapter 1 introduces key concepts and issues within contemporary analytic philosophy relevant to responsibility ethics; these concepts and issues resurface toward the end of the book when Jung puts them in dialogue with the ethical theories of Niebuhr and Levinas. Chapter 2 reconstructs the philosophical and theological background of Niebuhr’s moral theory, engaging a number of influential thinkers—Friedrich Schleiermacher, Albrecht Ritschl, Ernst Troeltsch, Karl Barth, Josiah Royce, and Martin Buber—who shaped his thought. Chapter 3 examines more closely Niebuhr’s responsibility ethics itself. In the next two chapters, Jung applies the same structure of analysis to Levinas’s ethical theory: he considers Levinas’s philosophical and theological context; engages the works of Edmund Husserl, Martin Heidegger, Franz Rosenzweig, and Buber; and then exposits Levinas’s own distinct position. Jung traverses and navigates complex and divergent concepts and ideas proposed by Niebuhr and Levinas with clarity and finesse. His purpose is to interpret their arguments in light of their respective positions in ethical theory. In the final two chapters, Jung’s work turns more explicitly constructive when he puts their theories into conversation with analytic philosophy.The specialist in Niebuhr or Levinas studies may find that Jung’s attempts to clarify their thought with foreign, extrinsic categories do violence to their works. Indeed, on occasion Jung seems to shoehorn their ideas into analytical concepts that may not do full justice to the full breadth of their thought. For instance, Jung rightly indicates that Levinas rejects a certain kind of abstract ethical universalism on the basis of his emphasis on the concrete relation to the particular other. But to conclude from this that he is an ethical particularist does not adequately account for the categorically imperative nature of the ethical demands and responsibility to the other that Levinas proposes. In other words, it seems to me that Levinas offers a form of ethical universalism that begins precisely in the concrete situation without collapsing into an ethical particularism.Despite these minor reservations, Jung’s work is to be commended not only for its excellent exposition and rigorous studies of Niebuhr and Levinas but also for its successful attempt overall to clarify and give greater coherence to their ideas with the tools of analytic philosophy. In so doing, Jung provides robust theoretical reflection on responsibility ethics in a time of augmented human power and capacities. [End Page 224]Michael SohnCleveland State UniversityCopyright © 2014 Society of Christian Ethics... (shrink)

In 2022, students at North American universities with third-dose COVID-19 vaccine mandates risk disenrolment if unvaccinated. To assess the appropriateness of booster mandates in this age group, we combine empirical risk-benefit assessment and ethical analysis. To prevent one COVID-19 hospitalisation over a 6-month period, we estimate that 31 207–42 836 young adults aged 18–29 years must receive a third mRNA vaccine. Booster mandates in young adults are expected to cause a net harm: per COVID-19 hospitalisation prevented, we anticipate at least (...) 18.5 serious adverse events from mRNA vaccines, including 1.5–4.6 booster-associated myopericarditis cases in males (typically requiring hospitalisation). We also anticipate 1430–4626 cases of grade ≥3 reactogenicity interfering with daily activities (although typically not requiring hospitalisation). University booster mandates are unethical because they: (1) are not based on an updated (Omicron era) stratified risk-benefit assessment for this age group; (2) may result in a net harm to healthy young adults; (3) are not proportionate: expected harms are not outweighed by public health benefits given modest and transient effectiveness of vaccines against transmission; (4) violate the reciprocity principle because serious vaccine-related harms are not reliably compensated due to gaps in vaccine injury schemes; and (5) may result in wider social harms. We consider counterarguments including efforts to increase safety on campus but find these are fraught with limitations and little scientific support. Finally, we discuss the policy relevance of our analysis for primary series COVID-19 vaccine mandates. (shrink)

Corporate social responsibility involvement and disclosure has been becoming increasingly popular among US public firms, including those that qualify as real estate investment trusts. This paper aims to discover the relationship between CSR involvement and potential determinants such as growth opportunities, profitability, visibility, and agency costs. Types of CSR involvement are assessed in terms of environmental, community, and governance disclosures and are quantified using word count from the company’s voluntary disclosure. Our results support the hypothesis that CSR has a strategic (...) element and that REITs have greater CSR involvement when they have greater growth and investment opportunities. When the type of disclosure is broken into subcategories, the results show that not all dimensions of CSR are alike: environmental, community, and governance CSR disclosures appear to be motivated by different sets of incentives and reasons. (shrink)

Objectives: To investigate why physicians label end-of-life acts as either ‘euthanasia/ending of life’ or ‘alleviation of symptoms/palliative or terminal sedation’, and to study the association of such labelling with intended reporting of these acts. Methods: Questionnaires were sent to a random, stratified sample of 2100 Dutch physicians. They were asked to label six hypothetical end-of-life cases: three ‘standard’ cases and three cases randomly selected, that varied according to type of medication, physician’s intention, type of patient request, patient’s life expectancy and (...) time until death. We identified the extent to which characteristics of cases are associated with physician’s labelling, with multilevel multivariable logistic regression. Results: The characteristics that contributed most to labelling cases as ‘euthanasia/ending of life’ were the administration of muscle relaxants or disproportional morphine. Other important factors were an intention to hasten death and a life expectancy of several months. Physicians were much more willing to report cases labelled as ‘euthanasia’ or ‘ending of life’ than other cases. Conclusions: Similar cases are not uniformly labelled. However, a physicians’ label is strongly associated with their willingness to report their acts. Differences in how physicians label similar acts impede complete societal control. Further education and debate could enhance the level of agreement about what is physician-assisted dying, and thus should be reported, and what not. (shrink)

This essay is meant as a form of philosophical exorcism. The goal is to dispel the view that there are general secular grounds for holding human germline genetic engineering to be intrinsically wrong, a malum in se, or a morally culpable violation of human nature. The essay endorses the view that major obligations of prudence and care attend the development of this technology. However, these justifiable moral concerns can be seen more clearly when one has dispelled what must, from a (...) secular perspective, be regarded as pseudo-issues. (shrink)

Antibiotic use triggers evolutionary and ecological responses from bacteria, leading to antibiotic resistance and harmful patient outcomes. Two complementary strategies support long-term antibiotic effectiveness: conservation of existing therapies and production of novel antibiotics. Conservation encompasses infection control, antibiotic stewardship, and other public health interventions to prevent infection, which reduce antibiotic demand. Production of new antibiotics allows physicians to replace existing drugs rendered less effective by resistance.In recent years, physicians and policymakers have raised concerns about the pipeline for new antibiotics, pointing (...) to a decline in the number of antibiotics approved since the 1980s. This trend has been attributed to high research and development costs, low reimbursement for antibiotics, and regulatory standards for review and approval. Professional societies and researchers around the world have called for renewed emphasis on antimicrobial stewardship, while also supporting antibiotic research and development through grants, changes to intellectual property laws to extend market exclusivity periods, and modification of premarket testing regulations to reduce antibiotic development time and expenses. (shrink)

In the maximal form of indirect development found in many taxa of marine invertebrates, embryonic cell lineages of fixed fate and limited division capacity give rise to the larval structures. The adult arises from set‐aside cells in the larva that are held out from the early embryonic specification processes, and that retain extensive proliferative capacity. We review the locations and fates of set‐aside cells in two protostomes, a lophophorate and a deuterostome. The distinct adult body plans of many phyla develop (...) from homologous set‐aside cells within homologous larvae. We argue that the stocks from which these phyla arose utilized these respective larvae, and the diversity of their adult body plans reflects diverse pattern formation processes executed in their set‐aside cell populations. Chordates and arthropods develop directly, but share adult characters with indirectly developing phyla. Thus the deuterostome and protostome stocks that were ancestral to chordates and arthropods, respectively, also utilized maximal indirect development. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Latina/o Social Ethics: Moving beyond Eurocentric Moral Thinking, and: Racism and God-Talk: A Latino/a PerspectiveKevin N. York-SimmonsLatina/o Social Ethics: Moving beyond Eurocentric Moral Thinking Miguel A. de La Torre, Waco Tex.: Baylor University Press, 2010. 160 pp. $24.95.Racism and God-Talk: A Latino/a Perspective Rubén Rosario Rodríguez New York: New York University Press, 2008. 320 pp. $24.00Although Latina/o theologians have contributed much to Christian moral discourse in recent decades, (...) the impact of these contributions has too often remained limited to other Latina/os and those with particular interests in liberation theologies. Miguel de La Torre and Rubén Rosario Rodríguez build on the contributions of theologians before them while challenging the broader theological community to take notice of these rich and provocative works.In four concise chapters, Miguel de La Torre’s Latina/o Social Ethics delivers a forceful criticism of prominent thinkers in the field of Christian ethics and offers a creative reconstruction of ethics from a Latina/o perspective. De La Torre offers a critique of “Euroamerican” Christian ethicists whose works have greatly influenced contemporary Christian moral discourse. He addresses the writings of Walter Rauschenbusch, Reinhold Niebuhr, Stanley Hauerwas, Anthony Campolo, Ron Sider, and Jim Wallis. De La Torre faults these theologians for the ways in which their moral thinking participates in the oppression and marginalization of Latina/os, either through their silence or through their endorsement of specific polices. De La Torre concludes that the legacy of cultural and economic privilege and the oppression of Latinas/os are so [End Page 199] deeply embedded in the Eurocentric thinking that has dominated the field of Christian ethics that it cannot be the foundation for Latino social ethics.De La Torre’s aim is to “move beyond” Eurocentric modes of thinking rather than dwell on critique. This eagerness to move forward to the creative and constructive aspects of Latina/o ethics, however, limits the forcefulness of his critique of Euroamerican ethicists. De La Torre’s reading of Euroamerican ethics—and even the application of that term—is highly selective, both in terms of the thinkers chosen and the writings examined. While De La Torre’s criticisms of these thinkers are generally insightful and serve to illustrate his basic criticism of Eurocentric ethics, these criticisms are limited in their depth of analysis. De La Torre is less concerned with the broader historical and theological considerations at work in these Euroamerican ethicists than with their failures to adequately address issues of concern to Latinas/os.The second half of Latina/o Social Ethics moves to his constructive, or “reconstructive,” project. De La Torre reviews central concepts in the methodology of Latina/o social ethics, including lo cotidiano, nepantla, la lucha, en conjunto, and acompañamiento. De La Torre’s explanation of these terms is brief and accessible. Moving beyond these concepts, the fourth chapter of Latina/o Social Ethics offers a creative approach to a liberative ethics that draws on Christian tradition as well as broader Hispanic cultural resources, including folk characters and themes of the trickster found in Afro-Caribbean religious traditions. De La Torre addresses the concern for how to imagine a Christian ethics with a role for the trickster, including identifying trickster characters and themes in the Bible. His “disruptive ethics” challenges the preference for order over justice that has characterized Eurocentric ethics, for which he provides helpful examples. De La Torre is clearly concerned with imperialism, immigration, and free trade, yet it is unclear what justice means in those contexts. Perhaps due to the powerlessness of marginalized Latina/os, criticisms of injustice weigh far more heavily than visions of justice.The concise length of this book broadens its appeal. Academics unfamiliar with some of the concepts and methodologies of Latina/o theologians will find this short introduction a useful starting point. This provocative book would also be a welcome addition to the classroom, either in part or in its entirety.In contrast to De La Torre’s short work, Rubén Rosario Rodríguez sets a broader and more ambitious task in his Racism and God-Talk. His project... (shrink)

The economic distinction between technological and market information offers a useful guide to the relationship between information and policy. The two types create different problems for markets and require different emphases in public policy, focusing on either the production or the distribution of information. The interaction of the two types creates familiar policy problems such as underinvestment in information, adverse selection and moral hazard. Indicators and other means of dealing with such problems constitute policies and demonstrate not only the importance (...) of information for policy but the necessity of policy for information. (shrink)

Several types of definitions and means of assessing welfare are discussed in an attempt to reconcile differences which may be counter-productive in addressing welfare issues. Various groups should use similar terminology and it is suggested that well-being be used in the context of the current state of the animal, while welfare refer to a more general concept including past, present and future implications for the animal's well-being. Legal, public and technical definitions of welfare serve different purposes and will necessarily differ. (...) All of these definitions are interdependent and are affected by, and affect, each other. It is suggested that all definitions should attempt to reflect the animals' perspective on their own welfare. Although the ideal means of assessing welfare may lie in determining animals' mental experiences, our ability to do this is limited at this time. A more practical approach is to assess several behavioural, physiological and pathological variables. Reliance on a specific variable or a "cut-off" point may be appropriate in a legal definition of welfare, but should be avoided in scientific studies. The study of animal welfare should not focus only on assessing well-being or the effects of poor welfare, but should also determine behavioural, physiological and pathological factors which predispose animals to environmental stressors. Only then can we focus on developing improved management systems rather than eliminating poor ones. (shrink)

All current versions of ethics for human interaction with animals are based on theories originally developed for relationships between humans or for human understanding of the environment. The perceived analogies between relationships among humans those theories were designed for and the relationships between human and animals have led to specifically revised and adapted theories for ethical interaction between humans and animals. In this essay I propose two further analogies that I develop into one core argument to cover specific issues in (...) human–animal relationships not yet adequately addressed. First I adapt the ethical theory designed for use between human professionals and their clients for analogous use in the power relationship between humans and animals; second I similarly adapt the ethical theory designed for interactions between humans and the global environment. I use elephants as example of an animal species and they stand as proxy for all similar animal species. The overall argument justifies moral duties for humanity to protect both species and the global biosphere as home for all living organisms. (shrink)

If we were to name the two greatest mathematicians of antiquity, we would probably choose Archimedes and Euclid. The first excelled in research, the second in synthesis or system. The synthesis or system is closely associated with the theory or philosophy of that subject; and Euclid's Elements, which has been characterized as “one of the noblest monuments of antiquity”, is the best concrete instance of the theory of mathematics according to the ancient Greeks. Now Aristotle had a theory of mathematics, (...) although he was not a practicing mathematician. It is the purpose of this article to show that the mathematical method according to Aristotle is superior to and more modern than that according to Euclid. For references to Aristotle's works we shall use pages and lines according to the standard Bekker's edition. By “a number” we shall mean a positive integer or a whole number. We proceed to a brief outline of Euclid's Elements. (shrink)

The famous passage in which Plotinus declares that fine art, so far from simply reproducing nature, ‘goes back to the Reason-principles from which nature herself emanates,’ has hitherto been generally regarded as a tacit criticism of Plato's teaching, and as an original contribution to the philosophy of art involving a rupture with the entire previous tradition of Greek aesthetic theory. Yet Plotinus introduces it, not as if he were proclaiming a new gospel, but almost casually, as a subordinate link in (...) his discussion of Intelligible Beauty. And though his respect for Plato was not the half-superstitious reverence of the later Neoplatonists, he was at all times more zealous to walk in Plato's footsteps than to correct or criticize him, tacitly or otherwise. Moreover, can it be said with certainty that his doctrine is in itself opposed to Plato's? That question can be answered only by a detailed examination of Plato's theory of art—a task which I hope to accomplish elsewhere. In the present article, postponing all enquiry into the relation between these two aesthetic theories, I shall endeavour to show that the teaching of Plotinus was not a sudden innovation, but the natural and indeed inevitable outcome of preceding thought. (shrink)

In this celebrated sentence Thucydides gives his opinion more specifically than anywhere in the narrative of Books 6 and 7 on the reasons for the failure of the Sicilian expedition. Unfortunately, however, he expresses his views with some lack of clarity, and this has led to disagreement among modern scholars who have sought to determine precisely what he means. It is also unfortunate that he does not state the evidence upon which he bases his conclusion that the expedition failed because (...) of struggles for political leadership at Athens. The main purpose of this paper is to consider the meaning and implications of this sentence, which can, I believe, be clarified by reference to other passages in which Thucydides uses when debating the causes of past actions. A closely allied problem, that of the relationship between this sentence and the narrative of Books 6 and 7, will also be discussed. A. W. Gomme has maintained that this relationship throws some light upon the date of composition of Books 6 and 7. There is no doubt whatever that the sentence was written at or after the end of the Peloponnesian war , and if there are differences of outlook, even inconsistencies, between it and the narrative which show that Thucydides cannot have written, or at any rate conceived, both at the same time, he almost certainly wrote the narrative before the end of the war.2 In my opinion there is inconsistency on one point only, but here the inconsistency is sufficiently marked to suggest not only that Books 6 and 7 were written considerably earlier than 2. 65. 11, but that they were written within the next few years after the conclusion of the Sicilian campaign. (shrink)

One area of language research that has received a great deal of attention, both theoretical and empirical, is the use of anaphoric expressions. Such expressions can be thought of as serving two functions: the primary function is to refer back to a referent from previous discourse, and the secondary, but no less important, function is to help provide discourse coherence and structure. Third person pronouns such as he or she are anaphoric expressions par excellence, but fuller anaphoric expressions, including demonstrative (...) and definite noun phrases (NPs) such as that woman and the woman are also used in natural discourse. In this chapter we shall focus primarily on issues concerning definite NP anaphor resolution, and in particular we shall examine the interaction of two factors that are related to the identification of antecedents: the focus status of the antecedent and the semantic relationship between the antecedent and the anaphor (including semantic overlap). After presenting these factors, we will discuss one particular approach to anaphor resolution, Almor's (1999) Informational Load Hypothesis (ILH), and present three experiments that examined the findings presented in Almor (1999). The results of these experiments will lead us to consider in more detail the secondary, discourse-structuring function of anaphoric expressions. (shrink)

In this article I deal with difficulties, textual and exegetical, in ten passages of the Agamemnon. In some passages there is wide agreement on the sense required, but not on the remedies proposed for a corrupt reading: here I venture to put forward fresh proposals that seem to possess a reasonable1 degree of palaeo-graphical probability . In another passage I argue for a new interpretation with its appropriate emendation . In some cases where the sense is hardly in doubt and (...) the text not certainly corrupt, I propose what seems on linguistic or other grounds a preferable reading , or I argue in favour of some other scholar's proposal . Finally, where there can be little, if any, likelihood of successful restoration, I offer a tentative suggestion which may give at least an approximation to the original text. (shrink)

This paper focuses on the preliminary evaluation of expressions of moral sentiment under conditions of cultural pluralism. The advance of science and technology puts ever new power over nature in human hands, and if this new power is to more fully serve human ends, then it must become the means or material of human virtue. This prospect poses the question of the relationship between power and virtue, and equally, the question of how scientific advances may be understood to enter into (...) a pluralism of moral doctrines and deliberations. Taking a page from the philosophy of science, the present approach examines the relationship between scientific advances and moral evaluations of developing practices as mediated by contemporary accounts of the virtues of hypotheses. If we conceive of expressions of moral sentiment as hypotheses for the amendment or expansion of existing moral doctrines in the light of new possibilities for action, then this suggests that expressions of moral sentiment may be evaluated, in a preliminary way, by reference to standard lists of the virtues of hypotheses: refutability, conservatism, modesty or simplicity, precision, elegance, and generality. Expressions of moral sentiment are subject to preliminary evaluation, on cognitive grounds, by reference to their prospective integration and/or modification of on-going moral traditions. (shrink)

This essay proposes a re-evaluation of Dewey's work with emphasis upon the ability of his philosophy to effect a realistic reformulation and development of America's tradition of humanistic liberalism. Dewey combines the tough-minded realism (or naturalism), congenial to the scientific orientation of American philosophy, with a firm conviction of the need of values and revaluation in community life. I draw on recent work of Hilary Putnam on Dewey and argue for the viability of Dewey's conception of value inquiry. The value (...) of Dewey's work to American liberalism extends beyond the version of liberalism, from the 1930's and the 1940's with which is name is most closely associated. (shrink)

Book Description -/- Edmund Burke (1730-1797) was a friend and advocate of America during the political crisis of the 1760s and the 1770s, and he spoke out eloquently and forcefully in defense of the rights of the colonial subjects of the British empire—in America, Ireland and India alike. However, he is often best remembered for his extremely critical Reflections on the Revolution in France. The present volume is based on classic Burke, including his most famous writings and speeches on the (...) American Crisis. Though his efforts at conciliation with the American colonies ultimately failed, Burke is widely remembered, studied and venerated by liberal and conservative thinkers alike, for his elucidation and criticism of the excesses of empire and political excesses generally. Irish-born, Burke made his career as a British Whig statesman and Member of Parliament, but he was also a powerful writer of philosophical works in high literary style. -/- In the present volume, Burke’s ideas, ideals and arguments are explored and set in their original historical and political context. The volume places the reader in a position to understand the similarities and contrasts between the political philosophy of the Whig ascendancy in British politics and the republican political philosophy of the American founders. What comes to the fore is Burke’s twin emphasis on continuity and justice, the anti-rationalism of his opposition to directly applying abstract political theory to policy decisions, the pluralism of peoples and public mores within the empire, the crucial roles of political representation in good government, and the fundamental importance of the consent of the governed. -/- Was Burke a friend of a foe of revolution? Was he a “liberal” or a “conservative”? To what degree did he accept the political ideals of the American founders? How could he both defend the American protests and reject the claims of the French Revolution? Thomas Jefferson’s “Summary View of the Rights of British America” is included in the volume for comparison and contrast. This book presents a deeper understanding of Burke’s political thought by exploring the similarities and contrasts with founding ideals of America’s republican tradition. (shrink)

This paper proceeds from an analysis (Callaway 1992, pp. 239-240) of a role of conflict in the origin of value commitments, a pervasive sociological pattern in the development of unifying group values which transforms personal conflicts, or differences, into large-scale collective conflicts. I have urged that these forces are capable of distorting even the cognitive processes of science and that they are a chief reason why value claims are regarded as incapable of objective evaluation. The thesis of the present paper (...) is that romantic collectivism (uncritical attachment to an identification group) renders members passive with respect to the ideals or content embodied in collective identity and that this is often exploited to convert groups into instruments of personal power. The issue is examined by reference to Reinhold Niebuhr's 1932 thesis of the inevitability of group egoism and inter-group conflicts and an opposing pragmatist conception of moral development, self-identity, and the individual's relationship to reference communities. (shrink)

Gareth Evans'' proposal, as amended by Steven Neale –that a definite pronoun with a quantifiedantecedent that does not bind it has the sense ofa definite description – has been challenged inthe singular case by appeal to counter-examplesinvolving failure of the uniqueness condition forthe legitimacy of a singular description. Thischallenge is here extended to the plural.Counter-examples are provided by cases in which aplural description `the Fs'' does not denote,despite the propriety of the use of `they'' or`them'' it is to replace, because (...) of failure ofcumulativeness. A noncumulative predicate isnot distributive, and conditions for thelegitimacy of `the Fs'' designed to accommodatenondistributive `Fs'' are given in the context ofa two sorted theory with generalized quantifiers.Failure of cumulativeness is not to be confusedwith failure of maximality as Neale and othersdefine it. If not all Fs are Gs, `The Fs are Gs''is false; but it does not follow that `the Fs'' isillegitimate; and if `Fs'' is distributive. it isso only if there are no Fs. These differencesgranted, I give a partial defense of theEvans–Neale proposal from deficiencies in analternative based on the views of P. T.Geach. (shrink)